Tiprotec preserves endothelial function after cold ischemia and warm reperfusion: comparison between Saline, Custodiol and Tiprotec
نویسندگان
چکیده
Method Aortic transplantations were performed in Lewis rats. Aortic arches stored in Saline, Custodiol and Tiprotec solutions for 2 hours, then were transplanted into abdominal aorta. Two, 24 hours and 1 week after transplantation, the implanted grafts were harvested. Endothelium-dependent and-independent vasorelaxations were investigated in organ bath. DNA strand breaks were assessed by TUNEL-method, mRNA expressions by quantitative real-time PCR and the expression of CD-31 and a-SMA by immunochemistry.
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